GLP1R rs3765467 Polymorphism Is Associated with the Risk of Early Onset Type 2 Diabetes

Table 1

Clinical characteristics of the study population.

	Control	Onset age of T2DM (years)
		EOD ≤ 45	LOD > 45
Subjects (n)	145	137	179	—	—
Sex (M/F)	58/87	85/52	73/106	<0.001	0.887
Age (years)	53.1 ± 6.6	46.9 ± 10.3	60.3 ± 6.8	<0.001	<0.001
BMI (kg/m^2)	23.7 ± 3.3	26.0 ± 3.6	25.7 ± 3.8	<0.001	<0.001
Systolic blood pressure (mmHg)	122.6 ± 14.0	132.8 ± 18.1	137.8 ± 20.2	<0.001	<0.001
Diastolic blood pressure (mmHg)	78.1 ± 8.9	77.8 ± 11.1	79.9 ± 13.7	0.972	0.364
TG (mmol/L)	1.1 (0.7–1.8)	1.7 (1.1–3.0)	1.6 (1.1–2.6)	<0.001	<0.001
TC (mmol/L)	4.9 ± 0.9	5.1 ± 1.4	5.1 ± 1.6	0.291	0.263
LDL (mmol/L)	3.1 ± 0.7	3.3 ± 0.8	3.3 ± 0.8	0.107	0.118
HDL (mmol/L)	1.3 ± 0.3	1.0 ± 0.3	1.0 ± 0.3	<0.001	<0.001
HbA1c (%)	5.6 ± 0.3	9.4 ± 2.2	9.6 ± 2.8	<0.001	<0.001
GA (%)	13.2 ± 1.1	23.6 ± 7.6	26.1 ± 16.0	<0.001	<0.001
Fasting plasma glucose (mmol/l)	5.3 ± 0.4	8.8 ± 2.5	8.7 ± 2.3	<0.001	<0.001
2 h glucose (mmol/L)	6.4 ± 1.1	12.2 ± 4.0	13.3 ± 5.3	<0.001	<0.001
Fasting serum insulin (mU/L)	6.5 (4.2–8.7)	10.2 (7.0–15.2)	10.1 (6.0–16.2)	<0.001	<0.001
2 h insulin (mU/L)	30.7 (18.8–51.7)	38.5 (17.7–66.6)	38.3 (21.1–64.1)	0.193	0.082
HOMA-IR	1.5 (1.0–2.1)	3.8 (2.5–5.8)	3.7 (2.2–6.4)	<0.001	<0.001
HOMA-β	74.0 (48.6–101.1)	46.4 (26.4–78.2)	41.9 (23.1–75.5)	<0.001	<0.001

-value for comparison of the EOD and control groups. -value for comparison of the LOD and control groups.