Immunocytochemistry Profile of Benign Thyroid Nodules Not Responding to Thermal Ablation: A Retrospective Study

Table 4

Predictive value of composite biomarker CK-19 + Ki-67 for response to thermal ablation.

Marker	Outcome regrowth			Indicators of diagnostic performance % (CI)
	Yes	No	Total	Sen	Spe	PPV	NPV	AC
Score 2	3	4	7	23 (5–54)	85 (66–96)	43 (10–82)	70 (51–84)	65 (48–79)
Score 0-1	10	23	33
Total	13	27	40
Marker	Outcome retreatment			Indicators of diagnostic performance % (CI)
	Yes	No	Total	Sen	Spe	PPV	NPV	AC
Score 2	5	2	7	29 (10–56)	91 (72–99)	71 (30–96)	64 (45–80)	65 (48–79)
Score 0-1	12	21	33
Total	17	23	40

Sen is for sensistivity; Spe is for specificity; PPV is for positive predictive value; NPV is for negative predictive value; AC is for diagnostic accuracy.