Immunocytochemistry Profile of Benign Thyroid Nodules Not Responding to Thermal Ablation: A Retrospective Study
Table 3
Predictive value of biomarkers for response to thermal ablation.
Marker
FNAC samples
Outcome regrowth
Indicators of diagnostic performance % (CI)
Yes
No
Total
Sen
Spe
PPV
NPV
AC
CK19
Negative
13
21
34
100 (66–100)
22 (9–42)
38 (22–56)
100 (42–100)
47 (32–64)
Positive
0
6
6
Total
13
27
40
Ki67
Positive
3
6
9
21 (5–51)
81 (62–92)
33 (7–70)
69 (52–84)
62 (46–76)
Negative
11
25
36
Total
14
31
45
Marker
FNAC samples
Outcome retreatment
Indicators of diagnostic performance % (CI)
Yes
No
Total
Sen
Spe
PPV
NPV
AC
CK19
Negative
17
17
34
100 (73–100)
26 (10–48)
50 (32–68)
100 (42–100)
57 (41–73)
Positive
0
6
6
Total
17
23
40
Ki67
Positive
6
3
9
32 (13–57)
88 (70–98)
67 (30–93)
64 (46–79)
64 (49-–8)
Negative
13
23
36
Total
19
26
45
Sen is for sensistivity; Spe is for specificity; PPV is for positive predictive value; NPV is for negative predictive value; AC is for diagnostic accuracy.
