Association between Intrapancreatic Fat Deposition and Lower High-Density Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DM

Table 1

Characteristics of study individuals.

Parameters	Healthy controls (n = 20)	T2DM (n = 80)
Male sex, n (%)	13 (65)	60 (75)	0.404
Age (years)	42.55 ± 13.14	42.89 ± 10.93	0.753
BMI (kg/m^2)	21.37 ± 1.85	29.74 ± 4.81	<0.001
IPFD (%)	6.35 (5.12–8.96)	12.34 (9.19–16.60)	<0.001
FBG (mmol/L)	4.69 (4.46–4.85)	9.98 (8.25–12.40)	<0.001
FINS (μU/mL)	5.75 (4.60–6.48)	10.85 (8.25–15.25)	<0.001
HbA1c (mmol/mol)	5.15 (5.10–5.30)	10.30 (8.90–11.33)	<0.001
HOMA-IR	1.22 (0.94–1.42)	4.83(3.74–6.77)	<0.001
HOMA-β (%)	89.26 (71.26–115.70)	34.05 (21.64–59.20)	<0.001
TC (mmol/L)	4.70 (4.26–4.99)	5.43 (4.61–6.02)	<0.001
TG (mmol/L)	0.94 (0.64–1.55)	2.22 (1.57–4.05)	<0.001
LDL-C (mmol/L)	2.73 ± 0.61	3.10 ± 1.08	0.050
HDL-C (mmol/L)	1.29 (1.08–1.66)	0.90 (0.80–1.10)	<0.001

Data are expressed as mean ± SD, median (interquartile range), or n (%). BMI, body mass index; FBG, fasting blood glucose; FINS, fasting insulin; HbA1c, hemoglobin A1c; HOMA-IR, homeostasis model assessment of insulin resistance; HOMA-β, homeostasis model assessment of β-cell function; TC, total cholesterol; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol. . The significance of bold values indicates that the differences of these parameters between the two groups were statistically significant (P value < 0.05).