International Journal of Endocrinology

Research Article

Correlation between the Severity of Metabolic Dysfunction-Associated Fatty Liver Disease and Serum Uric Acid to Serum Creatinine Ratio

Table 1

Characteristics of study participants (n = 228).


	Mild MAFLD and non-MAFLD (n = 175)	Moderate-severeMAFLD (n = 53)

Male [n (%)]	122 (69.7%)	45 (84.9%)	0.029
Female [n (%)]	53 (30.3%)	8 (15.1%)	0.029
Age (years)	47.0 (41.0–55.0)	48.0 (36.5–53.0)	0.266
BMI (kg/m²)	26.92 ± 3.02	29.39 ± 3.74	<0.001
Liver CT value	50.39 ± 7.36	30.63 ± 6.73	<0.001
Liver/spleen CT ratio	0.933 (0.847–1.078)	0.609 (0.488–0.671)	<0.001
ALT (mmol/L)	30.0 (21.0–41.0)	45.0 (34.0–69.5)	<0.001
AST (mmol/L)	22.0 (18.0–26.0)	26.0 (21.5–35.5)	<0.001
TBil (μ·mol/L)	12.43 (9.20–16.78)	12.180 (9.965–17.165)	0.623
DBil (μ·mol/L)	1.94 (1.56–2.54)	2.250 (1.690–2.845)	0.103
sUA (μ·mol/L)	354.47 ± 79.48	412.77 ± 75.12	<0.001
sCr (μ·mol/L)	65.80 ± 14.62	69.16 ± 11.81	0.091
sUA/Cr	5.51 ± 1.19	6.14 ± 1.55	0.008
TG (mmol/L)	1.84 (1.32–2.83)	2.050 (1.485–2.570)	0.333
FPG (mmol/L)	5.57 (5.17–6.04)	5.690 (5.340–6.665)	0.075
Dyslipidemia (n (%))	136 (77.7%)	46 (86.8%)	0.149
Abnormal liver function (n (%))	69 (39.4%)	37 (69.8%)	<0.001
Hypertension (n (%))	50 (28.6%)	16 (30.2%)	0.820
Diabetes (n (%))	10 (5.7%)	5 (9.4%)	0.339
Abdominal obesity (n (%))	150 (85.7%)	46 (86.8%)	0.843
Smoking history (n (%))	60 (34.3%)	20 (37.7%)	0.645
Drinking history (n (%))	59 (33.7%)	24 (45.3%)	0.125

Data were expressed as mean ± standard deviation and analyzed by Student’s t-test when approximately normally distributed or otherwise expressed as median (25th–75th percentiles) and analyzed by the Mann–Whitney U test for continuous variables or expressed as number (percentage) and analyzed by chi-square test for categorical variables. MAFLD, metabolic-associated fatty liver disease; BMI, body mass index; CT, computed tomography; ALT, alanine transaminase; AST, aspartate aminotransferase; TBil, total bilirubin; DBil, direct bilirubin; sUA, serum uric acid; sCr, serum creatinine; sUA/Cr, serum uric acid to serum creatinine ratio; TG, triglyceride; TC, total cholesterol; FPG, fasting plasma glucose.