Research Article
Genetic Variants of SIRT1 Gene Promoter in Type 2 Diabetes
Table 2
Genotype distribution and allele frequencies of the SNPs in T2D patients and controls.
| | Genetic model | Genotypes | T2D (n = 218) (n (%)) | Controls (n = 358) (n (%)) | OR | value |
| | g.4540A > G (rs3740051) | | Codominant | AA | 113 (51.8) | 234 (65.4) | 1.00 | 0.005 | | AG | 94 (43.1) | 114 (31.8) | 1.71 (1.20–2.43) | | | GG | 11 (5.0) | 10 (2.8) | 2.28 (0.94–5.52) | | | Dominant | AA | 113 (51.8) | 234 (65.4) | 1.75 (1.24–2.47) | 0.001 | | AG + GG | 105 (48.2) | 124 (34.6) | | | | Recessive | AA + AG | 207 (95.0) | 348 (97.2) | 1.85 (0.77–4.43) | 0.162 | | GG | 11 (5.0) | 10 (2.8) | | | | Over-dominant | AA + GG | 124 (56.9) | 244 (68.2) | 1.62 (1.15–2.30) | 0.006 | | AG | 94 (43.1) | 114 (31.8) | | | | Allele | A | 320 (73.4) | 582 (81.3) | 1.57 (1.19–2.09) | 0.002 | | G | 116 (26.6) | 134 (18.7) | | | | g.4798A > C (rs932658) | | Codominant | AA | 167 (76.6) | 230 (64.2) | 1.00 | 0.007 | | AC | 48 (22.0) | 118 (33.0) | 0.56 (0.38–0.83) | | | CC | 3 (1.4) | 10 (2.8) | 0.41 (0.11–1.52) | | | Dominant | AA | 167 (76.6) | 230 (64.2) | 0.55 (0.38–0.80) | 0.002 | | AC + CC | 51 (23.4) | 128 (35.8) | | | | Recessive | AA + AC | 215 (98.6) | 348 (97.2) | 0.49 (0.13–1.78) | 0.277 | | CC | 3 (1.4) | 10 (2.8) | | | | Over-dominant | AA + CC | 170 (78.0) | 240 (67.0) | 0.57 (0.39–0.85) | 0.005 | | AC | 48 (22.0) | 118 (33.0) | | | | Allele | A | 382 (87.6) | 578 (80.7) | 0.59 (0.42–0.83) | 0.002 | | C | 54 (12.4) | 138 (19.3) | | | | g.4821G > T (rs35995735) | | Codominant | GG | 185 (84.9) | 341 (95.3) | 1.00 | <0.001 | | GT | 33 (15.1) | 16 (4.5) | 3.80 (2.04–7.09) | | | TT | 0 (0.0) | 1 (0.2) | — | | | Dominant | GG | 185 (84.9) | 341 (95.3) | 3.58 (1.94–6.60) | <0.001 | | GT + TT | 33 (15.1) | 17 (4.7) | | | | Recessive | GG + GT | 218 (100.0) | 357 (99.8) | — | 1.000 | | TT | 0 (0.0) | 1 (0.2) | | | | Over-dominant | GG + TT | 185 (84.9) | 342 95.5) | 3.81 (2.04–7.11) | <0.001 | | GT | 33 (15.1) | 16 (4.5) | | | | Allele | G | 403 (92.4) | 698 (97.5) | 3.18 (1.77–5.71) | <0.001 | | T | 33 (7.6) | 18 (2.5) | | | | g.4916A > G (rs3740053) | | Codominant | AA | 115 (52.8) | 221 (61.7) | 1.00 | 0.100 | | AG | 91 (41.7) | 123 (34.4) | 1.42 (1.00–2.02) | | | GG | 12 (5.5) | 14 (3.9) | 1.65 (0.74–3.68) | | | Dominant | AA | 115 (52.8) | 221 (61.7) | 1.45 (1.03–2.03) | 0.034 | | AG + GG | 103 (47.2) | 137 (38.3) | | | | Recessive | AA + AG | 206 (94.5) | 344 (96.1) | 1.43 (0.65–3.15) | 0.371 | | GG | 12 (5.5) | 14 (3.9) | | | | Over-dominant | AA + GG | 127 (58.3) | 235 (65.6) | 1.37 (0.97–1.94) | 0.075 | | AG | 91 (41.7) | 123 (34.4) | | | | Allele | A | 321 (73.6) | 565 (78.9) | 1.34 (1.02–1.78) | 0.039 | | G | 115 (26.4) | 151 (21.1) | | | | | (n (%)) | (n (%)) | | | | g.4922G > C (rs2394443) | | Codominant | GG | 167 (76.6) | 230 (64.2) | 1.00 | 0.007 | | GC | 48 (22.0) | 118 (33.0) | 0.56 (0.38–0.83) | | | CC | 3 (1.4) | 10 (2.8) | 0.41 (0.11–1.52) | | | Dominant | GG | 167 (76.6) | 230 (64.2) | 0.55 (0.38–0.80) | 0.002 | | GC + CC | 51 (23.4) | 128 (35.8) | | | | Recessive | GG + GC | 215 (98.6) | 348 (97.2) | 0.49 (0.13–1.78) | 0.277 | | CC | 3 (1.4) | 10 (2.8) | | | | Over-dominant | GG + CC | 170 (78.0) | 240 (67.0) | 0.57 (0.39–0.85) | 0.005 | | GC | 48 (22.0) | 118 (33.0) | | | | Allele | G | 382 (87.6) | 578 (80.7) | 0.59 (0.42–0.83) | 0.002 | | C | 54 (12.4) | 138 (19.3) | | |
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OR: odds ratio. value: comparison of the genotype frequencies between T2D patients and controls. P values less than 0.05 were shown in bold. |
