International Journal of Endocrinology

Research Article

Association between the Triglyceride Glucose Index and Hyperuricemia in Patients with Primary Hypertension: A Cross-Sectional Study

Table 6

Effect modification of TyG on SUA in different models, as stratified by grades of hypertension.


	Nonadjusted		Model 1		Model 2		Model 3
	β coefficient (95% CI)	value	β coefficient (95% CI)	value	β coefficient (95% CI)	value	β coefficient (95% CI)	value

Grades 1-2 hypertension
tTyG	48.66 (39.3–58.03)	<0.001	44.72 (35.15–54.28)	<0.001	32.71 (23.9–41.53)	<0.001	28.72 (18.91–38.53)	<0.001
Tertiles
Q1	0 (ref)		0 (ref)		0 (ref)		0 (ref)
Q2	35.22 (22.55–47.9)	<0.001	32.79 (20.15–45.43)	<0.001	23.56 (12.33–34.79)	<0.001	22.01 (10.55–33.46)	<0.001
Q3	59.52 (46.52–72.52)	<0.001	53.76 (40.52–67)	<0.001	37.04 (24.96–49.12)	<0.001	30.82 (17.57–44.08)	<0.001
Trend. test	29.87 (23.38–36.37)	<0.001	27.02 (20.4–33.64)	<0.001	18.55 (12.51–24.59)	<0.001	15.54 (8.91–22.17)	<0.001
Grade 3 hypentension
tTyG	27.78 (18.46–37.09)	<0.001	17.46 (7.91–27.01)	<0.001	15 (6.38–23.62)	0.001	13.46 (3.95–22.97)	0.006
Tertiles
Q1	0 (ref)		0 (ref)		0 (ref)		0 (ref)
Q2	6.27 (−7.77–20.31)	0.38	−0.31 (−14.07–13.45)	0.97	2.1 (−10.24–14.44)	0.74	1.85 (−10.96–14.67)	0.78
Q3	38.44 (24.77–52.1)	<0.001	25.28 (11.51–39.05)	<0.001	25.11 (12.66–37.55)	<0.001	24.02 (10.34–37.69)	0.001
Trend. test	19.5 (12.66–26.35)	<0.001	12.92 (6.03–19.82)	<0.001	12.88 (6.66–19.11)	<0.001	12.5 (5.67–19.33)	<0.001
value for interaction
tTyG			0.001		0.002		0.002
Tertiles			0.004		0.02		0.02

Model 1 was adjusted for age; model 2 was adjusted for age, sex, ALB, ALT, AST, Scr, BUN, d-dimer, INR, eGFR, and hypertension grades; model 3 was adjusted for all covariables in model 2 plus LDL-C, HDL-C, and LPa. The enalapril group served as the reference group. value for the interaction test: 2-way interaction of TyG (total TyG and tertiles) and hypertension grades (grades 1-2 hypertension vs. grade 3 hypertension) with SUA. tTyG, total triglyceride-glucose index; other abbreviations as in Tables 1 and 2. Statistically significant P-values in bold for a better follow-up of the results.The bold values mean that the differences are significant. And in the 1st -3rd tertiles, the TyG index had a strong significant association with SUA in the grades 1 -2 hypertension group compared to that in the grade 3 hypertension group (P for interaction <0.05).