Association between the Triglyceride Glucose Index and Hyperuricemia in Patients with Primary Hypertension: A Cross-Sectional Study

Table 4

Association between the TyG index and HUA in different models.

TyG index	Crude model		Model 1		Model 2		Model 3
	OR (95% CI)	value	OR (95% CI)	value	OR (95% CI)	value	OR (95% CI)	value
Per 1 unit increase	2.47 (1.99–3.07)	<0.001	2.14 (1.71–2.68)	<0.001	1.98 (1.55–2.54)	<0.001	1.83 (1.40–2.39)	<0.001
Tertiles
Q1	1 (ref)		1 (ref)		1 (ref)		1 (ref)
Q2	1.66 (1.17–2.35)	0.004	1.51 (1.07–2.15)	0.02	1.48 (1.01–2.17)	0.045	1.45 (0.98–2.15)	0.06
Q3	3.31 (2.39–4.58)	<0.001	2.73 (1.96–3.8)	<0.001	2.60 (1.79–3.77)	<0.001	2.40 (1.60–3.60)	<0.001
Trend. test	1.84 (1.57–2.16)	<0.001	1.67 (1.42–1.97)	<0.001	1.63 (1.36–1.96)	<0.001	1.56 (1.28–1.91)	<0.001

Model 1 was adjusted for age; model 2 was adjusted for age, sex, ALB, ALT, AST, Scr, BUN, d-dimer, INR, eGFR, and hypertension grades; model 3 was adjusted for all covariables in model 2 plus LDL-C, HDL-C, and LPa. The enalapril group is the reference group. TyG, triglyceride-glucose index; HUA, hyperuricemia; ALB, serum albumin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Scr, blood creatinine; BUN, blood urea nitrogen; INR, international normalized ratio; eGFR, estimated glomerular filtration rate; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; LPa, lipoprotein a; OR, odds ratio; and CI, confidence interval. Statistically significant P-values in bold for a better follow-up of the results. The bold values mean that when the TyG index was assessed as tertiles, the incidence risks of HUA in the 2nd and 3rd tertiles were 1.45 (95% CI: 0.98 -2.15) and 2.40 (95% CI:1.60 -3.60) times greater than that in the lowest tertile (P for trend <0.001).