Association between the Triglyceride Glucose Index and Hyperuricemia in Patients with Primary Hypertension: A Cross-Sectional Study

Table 2

Results of univariate and multivariate analyses between HUA and all parameters.

Variable	Univariate analysis		Multivariate analysis
	OR (95% CI)	value	OR (95% CI)	value
TyG	2.47 (1.99–3.07)	<0.001	1.83 (1.40–2.39)	<0.001
Hypertension grades (1-2 vs.3)	1.24 (0.97–1.59)	0.08	1.13 (0.86–1.48)	0.40
Sex (male vs. female)	0.16 (0.12–0.21)	<0.001	0.24 (0.13–0.45)	<0.001
Age, years	0.97 (0.96–0.98)	<0.001	0.99 (0.98–1.01)	0.25
ALB, g/L	1.08 (1.04–1.12)	<0.001	1.05 (1.01–1.10)	0.03
hs-CRP, mg/L	0.99 (0.97–1.01)	0.36
LDL-C, mmol/L	0.90 (0.78–1.03)	0.13	0.94 (0.79–1.11)	0.44
TG, mmol/L	1.42 (1.28–1.57)	<0.001
HDL-C, mmol/L	0.27 (0.19–0.39)	<0.001	0.77 (0.49–1.23)	0.28
ALT, U/L	1.02 (1.02–1.03)	<0.001	1.01 (1.000–1.02)	0.20
AST, U/L	1.03 (1.02–1.04)	<0.001	1.01 (1.00–1.03)	0.08
Scr, μmol/L	1.04 (1.03–1.05)	<0.001	1.01 (0.97–1.04)	0.73
BUN, mmol/L	1.22 (1.12–1.33)	<0.001	1.21 (1.09–1.33)	<0.001
Glucose, mmol/L	1.13 (1.01–1.27)	0.03
HCY, μmol/L	1.02 (1.00–1.03)	0.004
LPa, mg/dL	0.999 (0.998–0.999)	0.001	1.00 (0.999–1.00)	0.29
TC, mmol/L	1.01 (0.90–1.11)	0.92
D-dimer, mg/L	0.80 (0.61–1.04)	0.09	1.02 (0.80–1.30)	0.90
INR	0.77 (0.22–2.66)	0.68	0.85 (0.22–3.20)	0.81
eGFR, mL/min per 1.73 m^2	0.99 (0.98–0.99)	<0.001	0.99 (0.97–1.02)	0.57

HUA, hyperuricemia; TyG, triglyceride-glucose index; ALB, serum albumin; hs-CRP, high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Scr, blood creatinine; BUN, blood urea nitrogen; HCY, homocysteine; LPa, lipoprotein a; TC, total cholesterol; INR, international normalized ratio; eGFR, estimated glomerular filtration rate; OR, odds ratio; and CI, confidence interval. Statistically significant P-values in bold for a better follow-up of the results. The bold values mean that TyG index, sex, age, ALB, HDL-C, AST, Scr, BUN, glucose, eGFR, ALT, LPa, and TG were associated with HUA in patients with primary hypertension (all P < 0.05). Furthermore, the multivariate analysis also revealed that the TyG index was positively associated with HUA after adjusting for potential confounding factors.