Research Article
CS27109, A Selective Thyroid Hormone Receptor-β Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models
Figure 2
Chemical structure, THR-β activity, and PK properties of CS27109: (a) chemical structure of several oral and liver-targeted THR-β agonists, including KB-141, VK2809, MGL3196, and CS27109, (b) THR-α and THR-β activity for each compound were determined by a luciferase reporter gene assay, (c) hERG test of CS27109 was conducted by the QPatch HTX, (d) mouse, and (e) rat PK studies for CS27109 and MGL3196.
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