Circulating Adiponectin Levels Are Inversely Associated with Mortality and Respiratory Failure in Patients Hospitalized with COVID-19

Table 2

Levels of circulating leptin and adiponectin in different subgroups of patients hospitalized with COVID-19.

	Leptin (ng/mL), median [IQR]	Adiponectin (µg/mL), median [IQR]
Age
≤60 years	8.2 [4.0, 12.4]	7.0 [4.5, 9.0]
61–80 years	7.8 [4.2, 13.9]	10.5 [5.6, 16.2]
≥81 years	6.0 [2.6, 13.3]	13.5 [7.3, 20.2]
p value	0.37	<0.001
Sex
Female	12.2 [4.9, 22.6]	12.5 [6.2, 18.8]
Male	5.7 [2.9, 10.2]	8.0 [5.1, 10.8]
p value	<0.001	0.01
Hypertension
Yes	7.4 [3.8, 12.9]	10.6 [6.9, 17.7]
No	6.2 [3.4, 14.3]	7.6 [4.3, 12.9]
p value	0.97	<0.01
AMI and/or heart failure
Yes	6.8 [3.9, 11.8]	8.2 [3.7, 9.2]
No	7.2 [3.8, 13.5]	9.0 [5.7, 14.6]
p value	0.81	0.23
Diabetes
Yes	6.9 [3.3, 12.8]	7.2 [3.8, 10.6]
No	7.2 [3.8, 14.0]	9.4 [6.1, 15.6]
p value	0.70	0.03
COPD
Yes	4.6 [3.8, 15.9]	14.8 [11.5, 21.2]
No	7.3 [3.7, 13.0]	8.9 [5.0, 14.2]
p value	0.84	0.02
Asthma
Yes	8.6 [5.6, 12.1]	10.2 [6.3, 15.7]
No	6.6 [3.4, 13.5]	8.9 [5.1, 14.5]
p value	0.48	0.51
Infiltration on chest X-ray
Yes	7.1 [3.8, 13.5]	9.0 [5.1, 15.6]
No	8.1 [3.5, 13.0]	8.3 [6.1, 10.6]
p value	0.94	0.42
Supplemental oxygen at admission
Yes	7.3 [4.5, 14.0]	9.2 [6.1, 14.4]
No	7.0 [2.8, 12.3]	8.5 [5.2, 14.6]
p value	0.21	0.93

AMI: acute myocardial infarction; COPD: chronic obstructive pulmonary disease.