Insulin Autoimmune Syndrome: A Systematic Review

Table 4

IAS-related detection and its advantages and shortcoming.

Tests	Advantages	Shortcomings
IAA	Common indicators, high detection rate	Not widely used yet; the kits on the market can only detect IgG IAA generally
Polyethylene glycol precipitation	IAA can be precipitated	Easy to be disturbed by macromolecular proteins and temperature
Gel filtration chromatography	It is more specific than the above two methods	Complex operation, high requirements for the laboratory, long time-consuming and expensive
Insulin/C-peptide molar ratio	It can assist diagnosis of IAS	It can be affected by exogenous insulin
HLA gene detection	Identify the pathogenic gene locus	Few domestic and foreign activities, high cost