Research Article
Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress
Figure 5
Knockdown of REDD1 inhibits HG-induced apoptosis in HK-2 cells. (a, b) Western blot of Bax, Bcl-2, and Cleaved Caspase-3 in HK-2 cells. (c, d) Apoptosis of HK-2 cells were analyzed by TUNEL assay. (e, f) Apoptosis rates of HK-2 cells were detected by flow cytometry analysis. Values are expressed as means ± SD (n = 6 per group). NG: 5.6 mM D-glucose; HG: 30 mM D-glucose; HG + C: 30 mM D-glucose plus scramble. HG + siREDD1: 30 mM D-glucose plus REDD1 siRNA. versus NG; #versus HG.
(a) |
(b) |
(c) |
(d) |
(e) |
(f) |