Influence of Obesity Parameters on Different Regional Patterns of Lymph Node Metastasis in Papillary Thyroid Cancer

Table 6

Relationship between BSA and different regional lymph node involvement in women.

	Univariate analysis			Multivariate analysis
	Nonobesity (BSA)	Obesity (BSA)	value	Nonobesity (BSA)	Obesity (BSA)	value
Rate of LNM
Rate of total LNM	331 (56.5%)	97 (61.8%)	0.233
Rate of CLNM	318 (54.3%)	95 (60.5%)	0.162
Rate of total LLNM	95 (16.2%)	39 (24.8%)	0.013	Ref	1.708 (1.119–2.609)	0.013
Rate of level II metastasis	44 (7.5%)	17 (10.8%)	0.178
Rate of level III metastasis	76 (13.0%)	26 (16.6%)	0.246
Rate of level IV metastasis	77 (13.1%)	35 (22.3%)	0.004	Ref	1.869 (1.214–2.962)	0.005
Rate of level V metastasis	19 (3.2%)	8 (5.1%)	0.270
Number of LNM
Number of CLNM^1	1.8 (2.7)	2.5 (3.1)	0.014	Ref	1.672 (1.149–2.432)	0.007
Number of LLNM	5.1 (3.8)	5.4 (4.7)	0.714
LNR
Central LNR	0.26 (0.32)	0.28 (0.31)	0.560
Lateral LNR	0.05 (0.36)	0.05 (0.11)	0.939
Pattern of LNM
Skip metastasis	13 (2.2%)	2 (1.3%)	0.669
MLLNM	83 (14.2%)	30 (19.1%)	0.125
Simultaneous metastasis in LC	76 (13.0%)	28 (17.8%)	0.119

The categorical variables were expressed as n (%). The continuous variables were expressed as the mean (standard deviations). Multivariate analysis was expressed as adjusted odds ratio (95% CI). BSA, body surface area; LN, lymph node metastasis; LLNM, lateral lymph node metastasis; CLNM, central lymph node metastasis; MLLNM, multiple lateral lymph node metastasis; LNR, lymph node ratio; and LC, lateral compartment. Age (per 10 years), glucose, thyroid stimulating hormone, cholesterol, triglyceride, tumor size, multifocality, extrathyroidal extension, and chronic lymphocytic thyroiditis as covariates to adjust OR value. ¹The cut-off point of number of CLNM is 2.5 in the multivariate analysis.