International Journal of Endocrinology

Research Article

Influence of Obesity Parameters on Different Regional Patterns of Lymph Node Metastasis in Papillary Thyroid Cancer

Table 3

Relationship between BFP and different regional lymph node involvement in men.


	Univariate analysis			Multivariate analysis
	Nonobesity (BFP)	Obesity (BFP)	value	Nonobesity (BFP)	Obesity (BFP)	value

Rate of LNM
Rate of total LNM	63 (56.8%)	124 (77.0%)	<0.001	Ref	2.553 (1.510–4.317)	<0.001
Rate of CLNM	60 (54.1%)	120 (74.5%)	<0.001	Ref	2.488 (1.487–4.163)	<0.001
Rate of total LLNM	21 (18.9%)	56 (34.8%)	0.004	Ref	2.286 (1.286–4.063)	0.005
Rate of level II metastasis	10 (9.0%)	23 (14.3%)	0.190
Rate of level III metastasis	18 (16.2%)	40 (24.8%)	0.088
Rate of level IV metastasis	17 (15.3%)	47 (29.2%)	0.008	Ref	1.647 (0.818–3.319)	0.162
Rate of level V metastasis	6 (5.4%)	15 (9.3%)	0.235

Number of LNM
Number of CLNM¹	1.9 (2.6)	3.1 (3.3)	0.001	Ref	2.034 (1.183–3.497)	0.010
Number of LLNM	5.3 (3.8)	5.6 (4.2)	0.764

LNR
Central LNR²	0.30 (0.35)	0.40 (0.35)	0.025	Ref	2.442 (1.471–4.054)	0.001
Lateral LNR	0.04 (0.11)	0.09 (0.31)	0.052

Pattern of LNM
Skip metastasis	3 (2.7%)	4 (2.5%)	0.911
MLLNM	17 (15.3%)	51 (31.7%)	0.002	Ref	2.564 (1.387–4.737)	0.003
Simultaneous metastasis in LC	16 (14.4%)	42 (26.1%)	0.021	Ref	2.096 (1.110–3.958)	0.023

The categorical variables were expressed as n (%). The continuous variables were expressed as the mean (standard deviations). Multivariate analysis was expressed as adjusted odds ratio (95% CI). BFP, body fat percentage; LNM, lymph node metastasis; LLNM, lateral lymph node metastasis; CLNM, central lymph node metastasis; MLLNM, multiple lateral lymph node metastasis; LNR, lymph node ratio; and LC, lateral compartment. Age (per 10 years), glucose, thyroid stimulating hormone, cholesterol, triglyceride, tumor size, multifocality, extrathyroidal extension, and chronic lymphocytic thyroiditis as covariates to adjust OR value. ¹The cut-off point of number of CLNM is 2 in the multivariate analysis. ²The cut-off point of number of Central LNR is 0.09 in the multivariate analysis.