Influence of Obesity Parameters on Different Regional Patterns of Lymph Node Metastasis in Papillary Thyroid Cancer

Table 2

Relationship between BMI and different regional lymph node involvement.

	Univariate analysis				Multivariate analysis
	Normal	Overweight	Obesity	value	Normal	Overweight	Obesity	value
Rate of LNM
Rate of total LNM	395 (61.1%)	191 (61.6%)	29 (50.0%)	0.233
Rate of CLNM	383 (59.2%)	183 (59.0%)	27 (46.6%)	0.168
Rate of total LLNM	134 (20.7%)	67 (21.6%)	10 (17.3%)	0.751
Rate of level II metastasis	63 (9.7%)	25 (8.1%)	6 (10.3%)	0.676
Rate of level III metastasis	104 (16.1%)	46 (14.8%)	10 (17.2%)	0.843
Rate of level IV metastasis	111 (17.2%)	57 (18.4%)	8 (13.8%)	0.683
Rate of level V metastasis	27 (4.2%)	21 (6.8%)	0 (0.0%)	0.013	Ref	1.758 (0.957–3.229)		0.069
Number of LNM
Number of CLNM	2.15 (2.95)	2.10 (2.70)	2.05 (3.10)	0.950
Number of LLNM	4.99 (3.65)	5.64 (4.80)	6.60 (3.27)	0.308
LNR
Central LNR	0.30 (0.33)	0.28 (0.32)	0.23 (0.30)	0.324
Lateral LNR	0.06 (0.37)	0.04 (0.10)	0.04 (0.10)	0.697
Pattern of LNM
Skip metastasis	12 (1.9%)	8 (2.6%)	2 (3.4%)	0.628
MLLNM	116 (17.9%)	57 (18.4%)	8 (13.8%)	0.699
Simultaneous metastasis in LC	107 (16.5%)	47 (15.2%)	8 (13.8%)	0.567

The categorical variables were expressed as n (%). The continuous variables were expressed as the mean (standard deviations). Multivariate analysis was expressed as adjusted odds ratio (95% CI). BMI, body mass index; OR, odds ratio; LNM, lymph node metastasis; LLNM, lateral lymph node metastasis; CLNM, central lymph node metastasis; MLLNM, multiple lateral lymph node metastasis; LNR, lymph node ratio; and LC, lateral compartment. Age (per 10 years), glucose, thyroid stimulating hormone, cholesterol, triglyceride, tumor size, multifocality, extrathyroidal extension, and chronic lymphocytic thyroiditis as covariates to adjust OR value.