Heterogeneity of IGF-1 Levels in Children with hCG-Induced Precocious Puberty

Table 1

Patients with dynamic reevaluation of IGF-1 level.

No	Site	Age	Pre-hCG(U/L)	Pre-AFP(U/L)	LH (U/L)	FSH (U/L)	T(ng/mL)	Height SD	Pre-therapy		Mid-therapy▲		Post-therapy		Final follow-up
									IGF-1 SD	IGFBP-3 SD	IGF-1 SD	IGFBP-3 SD	IGF-1 SD	IGFBP-3 SD	IGF-1 SD	IGFBP-3 SD
1		7	19.2	1.4	0.11	0.1	1.14	1.20	3.12	2.57	5.53	3.17	2.63
2	S	7	243.5	1.45	0.2	0.1	10.3	1.11	−2.48		−2.28	−2.44	−2.80	−0.88
3	RBG	7	112.7	2.56	0.1	0.1	7.4	1.40	0.85	−1.20	1.27	0.17	−0.65	−0.63	−0.04	0.61
4		8	50.79	293.3	0.1	0.1	6.17	0.93	0.88		1.66	−0.21	−0.75	−0.19	−1.11	−0.50
5	SP	7	152.8	2.48	0.21	0.34	9.57	1.20	−1.93	−3.25	−1.27	−3.18	−2.25	−2.92
6		7	1430	57.33	0.12	0.48	2.1	−0.35	1.31		1.68		0.41	0.94
7		4	378	80.85	0.21	0.29	2.33	3.82	2.03	2.43	3.08	1.96	1.51	2.10
8		5	8.29	0.782	0.1	0.1	4.48	4.12	4.12	2.09	2.96	2.22	2.11	1.76	0.69
9	LBG	8	73.87	1.66	0.13	1.57	8.37	0.56	0.16		−0.56	−1.20	0.87
10	LBG	7	60	32.46	0.1	0.1	8.19	−0.07	0.98		1.39		0.34	−1.32
11	SP	4	79.7	53.87	0.16	0.1	8.94	−0.79	0.65		−0.52		−0.58

, pineal region; S, sellar region; BG, basal ganglia region; hCG, human chorionic gonadotropin; AFP, alpha-fetoprotein; IGF-1, insulin-like growth factor 1; IGFBP-3, insulin-like growth factor binding protein 3; SD, standard deviation. ^▲The time when serum hCG level reduced to normal range (0–2.6 U/L).