Symptomatic Hypercalcemia in Patients with Primary Hyperparathyroidism Is Associated with Severity of Disease, Polypharmacy, and Comorbidity

<div>Differences in biochemical parameters between HS-PHPT and A-PHPT. Median plasma ionized calcium (a), serum PTH (b), serum total ALP activity (c), eGFR (d), and LDL cholesterol (e) significantly differed between HS-PHPT and A-PHPT patients. Dashed lines indicate normal reference ranges. Data are presented as median and range interquartile by box, and wisker plots represent minimum and maximum values. Statistical significance was determined by the Mann–Whitney test. HS-PHPT, hypercalcemic-related symptomatic PHPT (dark grey boxes); A-PHPT, asymptomatic PHPT (light grey boxes); PTH, parathormone; ALP, alkaline phosphatase; eGFR, estimated glomerular filtration rate; and LDL, low density lipoprotein.</div>

International Journal of Endocrinology

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Figure 1: Symptomatic Hypercalcemia in Patients with Primary Hyperparathyroidism Is Associated with Severity of Disease, Polypharmacy, and Comorbidity 

Figure 1 | Symptomatic Hypercalcemia in Patients with Primary Hyperparathyroidism Is Associated with Severity of Disease, Polypharmacy, and Comorbidity 