Research Article
Recent Trends in the Clinicopathological Features of Thyroid Nodules in Pediatric Patients: A Single Tertiary Center Experience over 25 Years
Table 2
Clinicopathological features of the pediatric patients with thyroid nodules according to age group.
| | | 0 to 10 (n = 24) | 11 to 15 (n = 79) | 16 to 18 (n = 112) | value |
| | Age, years (mean, SD) | 8 | ±2.358 | 14 | ±1.300 | 17 | ±0.833 | | | Sex | | | | | | | 0.002 | | Females | 12 | 50.0% | 61 | 77.2% | 93 | 83.0% | | | Males | 12 | 50.0% | 18 | 22.8% | 19 | 17.0% | | | Period of diagnosis | | | | | | | 0.892 | | 1990–1995 | 4 | 16.7% | 17 | 21.5% | 21 | 18.8% | | | 1996–2000 | 8 | 33.3% | 16 | 20.3% | 26 | 23.2% | | | 2001–2005 | 4 | 16.7% | 12 | 15.2% | 24 | 21.4% | | | 2006–2010 | 3 | 12.5% | 16 | 20.3% | 19 | 17.0% | | | 2011–2014 | 5 | 20.8% | 18 | 22.8% | 22 | 19.6% | | | Chief complaint leading to hospital admission | | | | | | | 0.197 | | Incidentaloma | 3 | 12.5% | 6 | 7.6% | 12 | 10.7% | | | Anterior neck palpable mass | 18 | 75.0% | 61 | 77.2% | 86 | 76.8% | | | Lateral neck palpable mass | 2 | 8.3% | 4 | 5.1% | 1 | 0.9% | | | Neck discomfort | 0 | | 2 | 2.5% | 1 | 0.9% | | | Hoarseness | 0 | | 2 | 2.5% | 0 | | | | Dyspnea | 1 | 4.2% | 1 | 1.3% | 1 | 0.9% | | | Unknown | 0 | | 3 | 3.8% | 11 | 9.8% | | | Fine needle aspiration at admission | | | | | | | 0.008 | | Yes | 20 | 83.3% | 67 | 84.8% | 74 | 66.1% | | | No | 4 | 16.7% | 12 | 15.2% | 38 | 33.9% | | | Initial cytology | | | | | | | 0.013 | | Nondiagnostic or unsatisfactory | 1 | 5.0% | 0 | | 0 | | | | Benign | 5 | 25.0% | 8 | 11.9% | 10 | 13.5% | | | Atypia of undetermined significance or follicular lesion of undetermined significance | 2 | 10.0% | 7 | 10.4% | 6 | 8.1% | | | Follicular neoplasm or suspicion of follicular neoplasm | 2 | 10.0% | 8 | 11.9% | 7 | 9.5% | | | Suspicion of malignancy | 4 | 20.0% | 5 | 7.5% | 2 | 2.7% | | | Malignant | 6 | 30.0% | 38 | 56.7% | 48 | 64.9% | | | Others (schwannoma and abscess) | 0 | | 1 | 1.5% | 1 | 1.4% | | | Final pathology after thyroidectomy | | | | | | | 0.291 | | Benign | 12 | 50.0% | 27 | 34.2% | 48 | 42.9% | | | Graves’ disease (diffuse hyperplasia) | 0 | | 7 | 25.9% | 30 | 62.5% | | | Adenomatous goiter/nodular hyperplasia | 6 | 50.0% | 11 | 40.7% | 9 | 18.8% | | | Hashimoto thyroiditis | 0 | | 0 | | 2 | 4.2% | | | Follicular adenoma | 4 | 33.3% | 7 | 25.9% | 7 | 14.6% | | | Hurthle cell adenoma | 1 | 8.3% | 1 | 3.7% | 0 | | | | Other (schwannoma and abscess) | 1 | 8.3% | 1 | 3.7% | 0 | | | | Malignant | 12 | 50.0% | 52 | 65.8% | 64 | 57.1% | | | Papillary thyroid cancer | 9 | 75.0% | 43 | 82.7% | 54 | 84.4% | | | Follicular thyroid cancer | 3 | 25.0% | 8 | 15.4% | 10 | 15.6% | | | Papillary with follicular thyroid cancer | 0 | | 1 | 1.9% | 0 | | | | Tumor size by pathology after thyroidectomy (cm) | 2.6 | (1.2–6.5) | 2.5 | (0.5–8.5) | 2.6 | (0.4–9.0) | 0.587 |
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