Vanadyl Sulfate Effects on Systemic Profiles of Metabolic Syndrome in Old Rats with Fructose-Induced Obesity

Figure 3

Vanadyl sulfate (VS) effect on calorie intake in old obese male Wistar rats. After obesity induced with high-fructose diet (HFD) during 28 weeks, stability in food and liquid consumption was observed during 4 weeks; then, insulin sensitizer treatment (metformin (MET) or VS) was applied from week 32 to week 40, using saline solution (SS) as a control. Kilocalories were estimated considering the amounts of food and fructose consumption registered per week. (a) Weekly food kilocalorie intake in all experimental groups. comparing VS treatment versus MET and/or SS treatment in both lean and obese animals. (b) Weekly fructose kilocalorie intake after treatment with insulin sensitizers. comparing HFD + VS treatment versus HFD + MET or SS treatment. (c) Weekly total kilocalorie intake in all experimental groups. comparing VS treatment versus MET and/or SS treatment in both lean and obese animals. Data are mean values ().

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