Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers

Table 2

Melatonin upregulated and/or activated molecular targets in breast, prostate, and ovary cancer.

	Synthesis of sexual hormones	Antiproliferation	Apoptosis	Cell cycle	Antiangiogenesis	Invasion-metastasis
Breast cancer	EST	p53, p21	p53, p21, caspase3, caspase7, caspase9, PARP, Bax, Bad, TGFb-1	p53, p21	Tie-2	E-cadherin, beta1-integrin, ROCK, cadherin13, GSK3β,
Prostate cancer		p53, p21, Kip1, IGFBP3, Per2, Clock, pAKT	p53, p21, Kip1, JNK, p38, PKC, caspase3, caspase8, caspase9, TGFb-1, PARP, Bax	p53,	miRNA3195, miRNA374b, HIF-1
Ovary cancer		p53,	p53, caspase3, Bax, PARP	p53,		FABP, ATP5F1B, HSP10