Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers

Table 1

Association of light-at-night (LAN) and melatonin levels with the different types of cancer; melatonin actions on sexual hormones synthesis, proliferation, apoptosis, cell cycle, invasion, and synergistic effects with other molecules in different cancers; yes¹: only described in one report; yes²: at least one contradictory study.

	LAN and cancer risk	Melatonin levels and cancer risk	Synthesis of sexual hormones	Antiproliferation	Apoptosis	Cell cycle	Antiangiogenesis	Invasion	Synergistic actions
Breast	Association	Inverse association	Inhibition	Yes	Yes	Delay G0-G1	Yes	Yes	Yes
Prostate	Association	Inverse association	Inhibition	Yes	Yes	Delay G0-G1	Yes	Not described	Yes^1
Ovary	No association	Not described	Not tested	Yes^2	Yes	Accumulation in G1	Not described	Yes	Yes