Regulation of Corticosteroidogenic Genes by MicroRNAs

Table 2

Bioinformatic miRNA target site predictions for corticosteroidogenic genes.

Gene	3′UTR length (base pairs)	MicroRNA.org		miRviewer		TargetScan		MicroCosm targets		Unique miRNAs with binding sites
CYP11B1	2022	151	(142)	4	(4)	436	(333)	33	(30)	390
CYP11B2	1428	89	(83)	10	(10)	323	(253)	6	(6)	288
CYP11A1	213	26	(26)	1	(1)	51	(50)	43	(43)	68
CYP17A1	171	24	(24)	0		35	(34)	23	(22)	59
CYP21A2	508	57	(56)	11	(10)	78	(70)	25	(22)	134
HSD3B2	414	68	(63)	0		73	(68)	46	(44)	125
StAR	624	110	(101)	4	(4)	273	(244)	11	(11)	285
HSD11B1	343	167	(135)	1	(1)	79	(72)	70	(65)	159
HSD11B2	550	82	(78)	4	(4)	116	(104)	33	(31)	159

The 3′UTR lengths of these 9 genes were identified using the UCSC Genome Browser Gateway and Ensembl Genome Browser. The number of predicted miRNA target sites from each database is listed, and the number of unique miRNAs predicted to bind each is shown in parentheses. The final column shows the cumulative number of miRNA target sites, with duplicates removed.