The Effect of Sitagliptin on the Regression of Carotid Intima-Media Thickening in Patients with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation

Table 3

Results of adjustment randomized comparisons.

	Adjusted odds ratio (95% CI)	P value
Mean intima-media thickness
Model 1	2.29 (1.17–4.47)	0.015
Model 2	2.27 (1.16–4.44)	0.016
Model 3	2.48 (1.24–4.93)	0.010
Model 4	2.60 (1.29–5.28)	0.008
Model 5	2.89 (1.34–6.24)	0.007
Right maximum intima-media thickness
Model 1	1.77 (1.00–3.13)	0.049
Model 2	1.78 (1.00–3.14)	0.049
Model 3	1.87 (1.04–3.34)	0.036
Model 4	1.88 (1.05–3.40)	0.035
Model 5	2.15 (1.12–4.14)	0.022
Left maximum intima-media thickness
Model 1	2.22 (1.25–3.92)	0.006
Model 2	2.24 (1.26–3.98)	0.006
Model 3	2.33 (1.28–4.22)	0.006
Model 4	2.43 (1.32–4.48)	0.004
Model 5	2.46 (1.28–4.73)	0.007

Multiple logistic regression analysis included the treatment group, age, gender, and baseline IMT (model 1); model 1 plus body mass index and current smoking (model 2); model 2 plus HbA1c, total cholesterol, high-density lipoprotein cholesterol, triglyceride, and systolic blood pressure (model 3); model 3 plus eGFR, use of angiotensin-converting enzyme/angiotensin II receptor blocker, use of statin, and use of antiplatelets (model 4); model 4 plus the use of oral hypoglycemic agents (model 5).