The Effect of Sitagliptin on the Regression of Carotid Intima-Media Thickening in Patients with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation
Table 2
Effects of sitagliptin on glucose metabolism, blood pressure lipid metabolism, and IMT.
Parameters
Sitagliptin group (n = 137)
Conventional group (n = 137)
P value
HbA1c at baseline (mmol/mol)
104 weeks (change from baseline)
−5.6 ± 11.4
−2.2 ± 10.0
0.004
Systolic blood pressure (mmHg)
104 weeks (change from baseline)
0 ± 19
3 ± 17
0.20
Total cholesterol at baseline (mmol/l)
104 weeks (% change from baseline)
−2.7 ± 15.6
−1.8 ± 14.6
0.63
HDL cholesterol at baseline (mmol/l)
104 weeks (% change from baseline)
0.2 ± 15.2
−0.5 ± 14.7
0.74
Triglyceride at baseline (mmol/l)
104 weeks (% change from baseline)
0.0 (−25.1, 44.6)
−1.6 (−24.6, 16.7)
0.35
Mean IMT (mm)
104 weeks (change from baseline)
−0.03 ± 0.17
0.02 ± 0.14
0.008
Right maximum IMT
104 weeks (change from baseline)
0.00 ± 0.35
0.02 ± 0.37
0.67
Left maximum IMT
104 weeks (change from baseline)
−0.06 ± 0.34
0.02 ± 0.29
0.033
Data are mean ± SD or median (range) values. Differences in parameters from baseline to 104 weeks between groups were analyzed by the Student t-test or Wilcoxon’s rank sum test. IMT, intima-media thickness.
