Clinical Study

The Effect of Sitagliptin on the Regression of Carotid Intima-Media Thickening in Patients with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation

Table 1

Clinical characteristics of patients of the two groups.

ParametersSitagliptin group (n = 137)Conventional group (n = 137)P value

Age (years)63.8 ± 9.763.6 ± 1.00.90
Gender (males) (%)83 (61)82 (60)1.00
Body mass index25.0 ± 4.325.0 ± 3.80.88
Current smoking30 (22)29 (21)0.22
Duration of diabetes (years)17.2 ± 8.517.3 ± 8.70.94
HbA1c at baseline (mmol/mol)64.9 ± 11.963.9 ± 10.60.45
Systolic blood pressure (mmHg)130 ± 16132 ± 140.88
Total cholesterol at baseline (mmol/l)5.02 ± 0.914.94 ± 0.860.50
HDL cholesterol at baseline (mmol/l)1.46 ± 0.371.39 ± 0.380.14
Triglyceride at baseline (mmol/l)1.13 (0.83, 1.55)1.17 (0.90, 1.72)0.22
eGFR (ml/min/1.73 m2)77.7 ± 21.279.7 ± 24.20.47
Mean IMT (mm)0.84 ± 0.190.84 ± 0.210.81
Right maximum IMT (mm)1.04 ± 0.291.06 ± 0.400.69
Left maximum IMT (mm)1.10 ± 0.321.11 ± 0.410.87
Use of oral glucose-lowering agents
 Metformin49 (36)48 (35)1.00
 Sulfonylurea17 (12)15 (11)0.85
 Glinides2 (1)19 (14)<0.001
 Thiazolidinediones13 (9)11 (8)0.83
α-Glucosidase inhibitor41 (30)42 (31)1.00
Others
 Angiotensin-converting enzyme inhibitors8 (6)4 (3)0.59
 Angiotensin II receptor blockers53 (39)69 (50)0.07
 Statins66 (48)63 (46)0.81
 Antiplatelet agents29 (21)30 (22)1.00

Data are number (%) of patients or mean ± SD values.
IMT, intima-media thickness; eGFR, glomerular filtration rate.