Long-Term Clinical Outcomes of Invasive Giant Prolactinomas after a Mean Ten-Year Followup

Table 4

Summary of persistent hyperprolactinemia analyses by univariate and multivariate COX regression analysis.

Variable	Univariate analysis		Multivariate analysis^&
	HR (95% CI)	value	HR (95% CI)	value
Age (≥25 y versus <25 y)	0.082 (0.007–0.929)	0.043	0.082 (0.007–0.929)	0.043
Gender (male versus female)	0.723 (0.12–4.65)	0.727
Final tumor volume (no remnant versus remnant)	1.434 (0.23–8.97)	0.7
Cavernous sinus invasion (bilateral versus unilateral)	0.612 (0.10–3.67)	0.59
Treatment strategy (BRC versus S + BRC)	1.6 (0.17–15.67)	0.679

Probability for stepwise: entry = 0.05 and removal = 0.1.
S + BRC: surgery + bromocriptine.