Valproic Acid, a Histone Deacetylase Inhibitor, in Combination with Paclitaxel for Anaplastic Thyroid Cancer: Results of a Multicenter Randomized Controlled Phase II/III Trial

Table 2

Pharmacokinetic parameters.

Pharmacokinetic parameters	Median (range)		value (Mann–Whitney)
	TAX	VPA + TAX
(ng/mL)	1155 (767–1749)	1134 (608–1565)	0.85
AUC (ng h/mL)	3490 (2177–4321)	3434 (2050–4137)	0.68
(1/h)	0.34 (0.18–0.56)	0.49 (0.41–0.56)	0.05
(h)	2.03 (1.24–3.94)	1.42 (1.25–1.69)	0.05
Cl (mL/h)	39858 (30189–71196)	41819 (30898–71012)	0.91
(mL)	52138 (43138–147388)	61452 (34164–142622)	0.58