Valproic Acid, a Histone Deacetylase Inhibitor, in Combination with Paclitaxel for Anaplastic Thyroid Cancer: Results of a Multicenter Randomized Controlled Phase II/III Trial

Table 1

Patient characteristics.

	TAX	VPA + TAX
Number of enrolled patients	14	11
Gender
(i) Male	8	5
(ii) Female	6	6
Age (years)
(i) Median	73.5	66
(ii) Range	62–83	44–80
Disease stage
(i) 4A	1	1
(ii) 4B	1	5
(iii) 4C	12	5
Distant metastasis
(i) Lymph nodes	5	4
(ii) Lung	7	2
Previous therapy
(i) Radiotherapy	6	7
(ii) Chemotherapy	4	7
(iii) Thyroidectomy (incomplete)	7 R0/R1 (1 R2)	8 R0/R1 (1 R2)

R0/R1: macroscopically complete resection; R2 resection with minimal macroscopical residual tumor.