Vitamin D and Osteoporosis in HIV/HCV Coinfected Patients: A Literature Review

Table 1

Characteristics of the selected studies.

Study, year	Country	Total; number	HIV+/HCV+; number	Control Group(s)	Age (yrs); HIV+/HCV+	Study design	Population study/setting	Topics
Mandorfer et al., 2015 [34]	USA	86	86		38.7 median	Cohort retrospective	HIV/HCV; coinfected	Vitamin D levels. Other variables and severity of liver disease
Dong et al., 2014 [22]	USA					Systematic review and meta-analysis	HIV/HCV; coinfected	Osteoporosis and fractures
Guzmán-Fulgencio et al., 2014 [31]	Spain	174	174	HIV/HCV; coinfection	40.8 median	Cross-sectional	HIV/HCV; coinfected	Prevalence of vitamin D levels and association with other parameters
Avihingsanon et al., 2014 [32]	Australia	331	130	Monoinfected HCV−; HIV/HCV; coinfection	42 median	Cross-sectional	HIV/HCV; coinfected	Vitamin D levels and virological response in coinfection treatment
Luetkemeyer et al., 2013 [20]	USA					Review	monoinfected HIV and HIV/HCV; coinfected	Bone metabolisms and vitamin D deficiency
Mandorfer et al., 2013 [35]	Austria	65	65	HIV/HCV; coinfection	38.6 median	Cross-sectional	HIV/HCV; coinfected	Vitamin D levels and virological response in coinfection treatment
Branch et al., 2013; [36]	USA	144	144	non-EVR^* HIV/HCV coinfected	48 median	Cohort; retrospective	HIV/HCV; coinfected genotype 1 treated in ACTG study	Vitamin D levels and virological response in coinfection treatment
El-Maouche et al., 2013 [33]	USA	116	116	HIV/HCV coinfection	49.9 median	Cohort prospective	HIV/HCV coinfected	Vitamin D levels and bone mineral density (BMD)
Linari et al., 2013 [37]	Italy	78	26	Monoinfected (HIV+)/Uninfected	45.8 mean	Cross-sectional	Haemophilia	Prevalence of hypovitaminosis D and BMD markers
Maalouf et al., 2013 [21]	USA	56.660	17.734	Monoinfected (HIV+)	44 median	Cohort retrospective	HIV-infected population	HCV-associated risk of osteoporotic fractures and severity of liver disease
Vecchi et al., 2012 [38]	Italy	120	41	Monoinfected (HIV+)/Uninfected	47 mean	Cohort prospective	HIV-infected population	Vitamin D levels and BMD; dairy calcium intake
Milazzo et al., 2011 [39]	Italy	237	93	Monoinfected HIV/Uninfected	45 median	Cross-sectional	HIV-infected population	Vitamin D levels and severity of liver disease

Early virologic response.