Low Magnesium Exacerbates Osteoporosis in Chronic Kidney Disease Patients with Diabetes

Table 3

Correlation of different serum Mg levels with osteoporosis and bone metabolism parameters.

Variables	Serum Mg (mg/dL)
	<1.82 ()	1.82–2.31 ()	>2.31 ()
Osteoporosis
With	4 (66.7)	13 (39.4)	5 (29.4)	0.314
Without	2 (33.3)	20 (60.6)	12 (70.6)
Bone metabolism parameters
iPTH (pg/mL)	32.2 (20.0–62.4)	86.4 (45.9–133.0)	126.0 (80.8–221.5)	0.007
Serum Ca (mg/dL)	9.0 (8.7–9.5)	8.9 (8.6–9.3)	8.7 (8.2–8.9)	0.018
Serum P (mg/dL)	3.5 (3.1–4.1)	3.9 (3.4–4.1)	4.4 (3.7–5.0)	0.026
ALK-P (U/L)	88.5 (74.3–102.4)	79.0 (66.5–89.8)	87.0 (79.0–116.5)	0.061
25(OH)D (ng/mL)	27.2 (17.7–37.3)	22.7 (18.5–28.0)	23.6 (14.6–28.0)	0.631
1,25(OH)2D (pg/mL)	24.0 (15.5–29.4)	16.6 (11.9–31.2)	15.4 (11.8–23.9)	0.516
Serum Ca/Mg ratio	5.1 (5.0–5.6)	4.1 (3.8–4.4)	3.4 (2.8–3.6)	<0.001
Serum value	31.2 (27.8–38.1)	33.8 (29.5–38.3)	37.4 (34.6–41.9)	0.128

(1) iPTH, intact parathyroid hormone; ALP, alkaline phosphatase; 25(OH)D, 25-hydroxyvitamin D; 1,25(OH)₂D, 1,25-dihydroxyvitamin D.
(2) Comparisons of continuous data between three groups were analyzed by Kruskal Wallis test. Data are median and range (25th pctl–75th pctl).
(3) Comparisons of categorical data between two groups were analyzed by Chi-square test. When cells have expected count less than 5, data were analyzed by Fisher’s Exact test. Data are number (), percent (%).
(4) A value less than 0.05 was considered statistically significant.