Review Article

Erectile Dysfunction in the Elderly: An Old Widespread Issue with Novel Treatment Perspectives

Table 2

Summarizing the possible treatment options for ED in elderly patients.

DrugDose (h)FrequencyAdvantagesSide effects

Sildenafil
Tadalafil
Vardenafil
Avanafil
25, 50*, 100 mg
2.5, 5, 10, 20 mg
2.5, 5, 10*, 20 mg
50, 100, 200 mg
4.6
17–21
4-5
5–10
On demand
or daily
Safe; available on demand as well as
continuous low dose
(vardenafil 2.5 mg, tadalafil 2.5 mg)
Headache, myalgia, back pain, blurred vision, facial flushing, nasal congestion, dizziness

Yohimbine5–15 mg0.25–2.5Three times
daily
Natural productHypertension, tachycardia, anxiety

Vacuum constriction device//On demandEffective in 90% of patients; not expensiveSkin necrosis, pai006E, cold penis, unnatural erection

Papaverine
PGE1
Phentolamine
30–110 mg
5–40  g
1.25–2 mg
1.5–2.5
0.30
0.19
On demandBroad efficacy, safety, and effecacy in neurogenic EDPriapism, pain, penile fibrosis, injection training requested

MUSE125, 250, 500,
1,000  g
0.30 On demandNo injections neededHypotension, pain, urethral burning, syncope, vaginal irritation in the partner

Penile prosthesis//On demandHigh satisfation ratesIrreversible, infection, erectile lenght loss, autoinflation

: plasma half-life; h: hours; *also available in orodispersable formulation (supralingual).