Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents
Table 3
Anthropometric and biochemical data with different AXL rs4802113 genotypes among boys and girls.
Boys
Girls
TT
TC
CC
TT
TC
CC
(n = 123)
(n = 170)
(n = 65)
(n = 108)
(n = 181)
(n = 80)
BMI (kg/m2)
22.0 ± 3.7
22.6 ± 3.8
21.9 ± 4.7
21.4 ± 3.6
21.1 ± 3.2
21.2 ± 3.0
WC (cm)
79.4 ± 10.3
80.8 ± 10.0
79.0 ± 11.9
75.8 ± 9.0
75.2 ± 7.7
76.1 ± 7.9
hsCRP (mg/L)
0.8 ± 1.2a
1.0 ± 1.4a
0.8 ± 1.3a
0.6 ± 0.8
0.6 ± 0.9
0.6 ± 0.9
TNF-α (pg/mL)
24.8 ± 5.5
26.2 ± 6.5
28.2 ± 10.1
24.0 ± 7.3
25.7 ± 8.3
26.6 ± 8.3
IL-6 (pg/mL)
3.0 ± 2.8
3.4 ± 2.7
3.7 ± 3.5
3.5 ± 3.0
2.9 ± 2.0
3.3 ± 2.9
Glucose (mg/dL)
93.4 ± 6.1
94.3 ± 6.0
93.4 ± 7.1
92.0 ± 6.9
91.0 ± 6.5
91.8 ± 6.2
Insulin (μU/mL)
14.8 ± 8.1
15.6 ± 9.7
14.5 ± 7.9
15.2 ± 7.3
14.1 ± 7.8
14.7 ± 7.4
HOMA-IR
3.4 ± 2.0
3.7 ± 2.3
3.4 ± 2.0
3.5 ± 1.7
3.2 ± 1.9
3.3 ± 1.7
Data are expressed as mean ± SD. BMI: body mass index; WC: waist circumference; HOMA-IR: homeostasis model assessment of insulin resistance; hsCRP: high-sensitivity C-reactive protein; TNF-α: tumor necrosis factor-α; IL-6: interleukin-6.
aTT versus TC versus CC, P < 0.05. All comparisons were analyzed using a general linear model after adjusting for age, Tanner stages, smoking status, drinking status, and physical activity.