7.5 g/day, 3x/school day (~200 school days/year) for 3 years
Erythritol group had significantly less tooth surfaces developing into enamel or dentin caries and significantly less enamel caries tooth surfaces developing into dentin caries when compared with sorbitol and xylitol; time of enamel or dentin caries lesions to develop and dentin caries to progress were significantly longer with erythritol
Double-blind randomized controlled prospective intervention trial (Examinations 3 years after cessation of all interventions in Honkala et al. (2014) study)
Erythritol, xylitol, or sorbitol
School children
129
~14-15
7.5 g/day, 3x/school day (~200 school days/year) for 3 years followed by 3 years without any intervention
No significant differences in decayed, missing, and filled teeth and surfaces between the intervention groups were noted However, erythritol group still had reduced percentages of surfaces developing enamel/dentin caries, dentin caries, or subject to dentist intervention compared to other groups
Falony et al. (manuscript submitted)
Salivary and plaque counts of S. mutans and salivary counts of Lactobacillus (Sampling from Honkala et al. (2014) study)
Erythritol, xylitol, or sorbitol
School children
156–165
~8-9
7.5 g/day, 3x/school day (~200 school days/year) for 3 years (tablets)
At years 1 and 3, a significant reduction in the weight of freshly collected dental plaque of the subjects occurred with erythritol No such changes with sorbitol or xylitol; no effect on the plaque levels of protein, glucose, glycerol, or calcium; erythritol was also generally associated with significantly lower counts of salivary and plaque S. mutans No effect on salivary Lactobacillus levels
4.5 g erythritol + 4.2 g maltitol/day 4.7 g xylitol + 4.6 g maltitol/day, 3x/day for up to 2 years with a 4-year follow-up (lozenges)
No evidence of caries reduction; however, final caries diagnoses were made 27 or 39 months after termination of the interventions, and the study subjects lived in a fluoridated area and exhibited low caries activity