Review Article
Production Methods for Hyaluronan
Table 4
A comparative view of technologies for manufacturing hyaluronan.
| | Advantages | Disadvantages |
| Extraction from animal materials | (i) Well-established technology | (i) Variation in product quality | (ii) Available raw material at low costs | (ii) Risk of polymer degradation | (iii) Product with very high up to 20 MDa | (iii) Risk of contamination with protein, nucleic acids, and viruses | (iv) Natural product | (iv) Extensive purification needed | | (v) Low yield |
| Bacterial production | (i) Mature technology | (i) Use of genetically modified organism (GMO) | (ii) High yield | (ii) Risk of contamination with bacterial endotoxins, proteins, nucleic acids, and heavy metals | (iii) Product with high (1–4 MDa) | |
| Enzymatic synthesis | (i) Versatile technology | (i) Emerging technology in development stage | (ii) Control of the of the products. Products up to 0.55–2.5 MDa and also defined oligosaccharides can be obtained | (ii) Technological and economic viability must still be demonstrated | (iii) No risks of contamination | | (iv) Constant product quality | |
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