International Journal of Cell Biology

Redox Status and Bioenergetics Liaison in Cancer and Neurodegeneration


Publishing date
31 Aug 2012
Status
Published
Submission deadline
13 Apr 2012

1Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy

2Department of Biochemistry and Molecular Biology, University of Salamanca, Plaza Doctores de la Reina, 37007 Salamanca, Spain

3Department of Genetics, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands


Redox Status and Bioenergetics Liaison in Cancer and Neurodegeneration

Description

Cells require a constant supply of energy to sustain fundamental biological processes such as growth, differentiation, and death. In heterotrophic organisms, glycolysis- and mitochondrial-driven oxidation of nutrients to produce ATP and the pentose-phosphate-pathway-dependent generation of NADPH provide, respectively, the energy and the reducing equivalents to cope with endergonic reactions. ATP and NADPH also oversee the control of intracellular redox homeostasis by balancing the generation of reactive oxygen and nitrogen species with their elimination through the synergistic action of antioxidant enzymes and thiol-containing antioxidants (e.g., glutathione and thioredoxin). An increasing body of evidence also reveals how bioenergetics and redox status crosstalk dictates the onset of several pathologies, notably cancer and neurodegenerative diseases.

We invite authors to submit original contributions, in the form of review or original research articles, that will enhance the comprehension of the molecular mechanisms underlying metabolic oxidative stress-relying disorders, support the development of potential new therapies, and further stimulate discussion in this important area of research. We are particularly interested in articles exploring possible converging points between the principal metabolic and redox alterations occurring in neurodegenerative diseases and cancer. Potential topics include, but are not limited to:

  • Identifying the implications of redox transduction mechanisms involved in cell response to stressful conditions
  • Revisiting the role of different metabolic pathways (e.g., glycolysis versus oxidative phosphorylation) in neuronal and cancer metabolism
  • Defining the defects of mitochondrial biogenesis, function, or turnover in physiological alteration underlying neoplastic transformation and neuronal demise
  • Characterizing the biochemical transformations of cancer cells and neurons (e.g., glutaminolytic pathway)
  • Elucidating the metabolic oxidative stress-dependent activation of apoptosis and autophagy in cancer and neurodegenerative, neuroinflammatory diseases
  • Recapitulating the developments in molecular genetics and molecular diagnostics of redox and metabolic markers

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijcb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 659645
  • - Editorial

Redox Status and Bioenergetics Liaison in Cancer and Neurodegeneration

Giuseppe Filomeni | Juan P. Bolaños | Pier Giorgio Mastroberardino
  • Special Issue
  • - Volume 2012
  • - Article ID 683897
  • - Review Article

Electromagnetic Fields, Oxidative Stress, and Neurodegeneration

Claudia Consales | Caterina Merla | ... | Barbara Benassi
  • Special Issue
  • - Volume 2012
  • - Article ID 139573
  • - Review Article

Brain Miffed by Macrophage Migration Inhibitory Factor

Nic E. Savaskan | Günter Fingerle-Rowson | ... | Ilker Y. Eyüpoglu
  • Special Issue
  • - Volume 2012
  • - Article ID 367934
  • - Review Article

Molecular Regulation of the Mitochondrial F1Fo-ATPsynthase: Physiological and Pathological Significance of the Inhibitory Factor 1 (IF 1 )

Danilo Faccenda | Michelangelo Campanella
  • Special Issue
  • - Volume 2012
  • - Article ID 463756
  • - Review Article

Redox Regulation of Protein Function via Cysteine S-Nitrosylation and Its Relevance to Neurodegenerative Diseases

Mohd Waseem Akhtar | Carmen R. Sunico | ... | Stuart A. Lipton
  • Special Issue
  • - Volume 2012
  • - Article ID 361872
  • - Review Article

Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation: Implications in Cancer and Neurodegeneration

Giuseppina Di Giacomo | Salvatore Rizza | ... | Giuseppe Filomeni
  • Special Issue
  • - Volume 2012
  • - Article ID 161837
  • - Review Article

TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State

Simone Cardaci | Maria Rosa Ciriolo
  • Special Issue
  • - Volume 2012
  • - Article ID 759583
  • - Review Article

Caloric Restriction and the Nutrient-Sensing PGC-1 in Mitochondrial Homeostasis: New Perspectives in Neurodegeneration

Daniele Lettieri Barbato | Sara Baldelli | ... | Maria Rosa Ciriolo
  • Special Issue
  • - Volume 2012
  • - Article ID 595976
  • - Review Article

Targeting Metabolism and Autophagy in the Context of Haematologic Malignancies

Versha Banerji | Spencer B. Gibson
  • Special Issue
  • - Volume 2012
  • - Article ID 703164
  • - Review Article

Redox Regulation of Cysteine-Dependent Enzymes in Neurodegeneration

Rodney P. Guttmann | Tamara J. Powell
International Journal of Cell Biology
 Journal metrics
Acceptance rate14%
Submission to final decision14 days
Acceptance to publication119 days
CiteScore4.430
Impact Factor-
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