Stellettin B Isolated from <i>Stelletta</i> Sp. Reduces Migration and Invasion of Hepatocellular Carcinoma Cells through Reducing Activation of the MAPKs and FAK/PI3K/AKT/mTOR Signaling Pathways

<div>Effects of Stellettin B on the MAPKs signaling pathway. HA22T and HepG2 cells were treated with different concentrations of Stellettin B (0, 6, 12, 18, and 24 <i>μ</i>g/mL) and cell lysates were collected for western blotting analysis. The MAPKs-related proteins were validated, including p38MAPK, <i>p</i>-p38MAPK, ERK, <i>p</i>-ERK, JNK, <i>p</i>-JNK, JUN, and <i>p</i>-JUN. Zero refers to cells treated with DMSO vehicle as a control. <i>β</i>-Actin was used as the internal control.</div>

International Journal of Cell Biology

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Figure 7

Figure 7: Stellettin B Isolated from <i>Stelletta</i> Sp. Reduces Migration and Invasion of Hepatocellular Carcinoma Cells through Reducing Activation of the MAPKs and FAK/PI3K/AKT/mTOR Signaling Pathways 

Figure 7 | Stellettin B Isolated from Stelletta Sp. Reduces Migration and Invasion of Hepatocellular Carcinoma Cells through Reducing Activation of the MAPKs and FAK/PI3K/AKT/mTOR Signaling Pathways 