Regulating inflammatory response Correlated with macrophage numbers and with MCP-1 protein expression in in the bronchoalveolar lavage (BAL) supernatant 27 binding sites on SARS-CoV-2 genome with the highest target scores
Binding to the complemented sequence which led to the recovery of the cytopathic effects Related to cytokine–cytokine receptor interactions, TNF, NF-κB, chemokines, Toll-like receptors, and the Jak–STAT signaling pathway
Targeting the 3-UTR binding sites on IL-6 gene in COVID-19 disease Suppressing LPS-induced p65 expression and cell apoptosis Decreasing the levels of inflammation and pulmonary injury
Predicted to have binding sites in the SARS-CoV-2 genome Alleviated LPS-induced inflammatory response and apoptosis A target in the development of anti-inflammation and antiapoptosis drugs for sepsis treatment
Attenuating the cell death, avoiding tissue damage by targeting synergistically the 3-UTR region of the TNF and IFN genes inhibiting their protein translation