miRNAs: The Key Regulator of COVID-19 Disease

Figure 3

Targeting viral miRNAs for therapeutic avenues. 1—inhibition of the viral miRNA function through antimiR; 2—blocking of viral miRNAs by miRNA sponge; 3—cleavage of viral miRNAs with ribozyme technique; 4—deletion of base pairs, disrupting the original miRNA sequence and causing its inactivation by CRISPR technique. Abbreviations: ACE2: angiotensin-converting enzyme; AGO2: argonaute 2; CRISPR: clustered regularly interspaced short palindromic repeats; TMPRSS2: transmembrane protease serine 2.