Exploring Seipin: From Biochemistry to Bioinformatics Predictions

Figure 5

Seipin gain-of-function. We are proposing 4 different general models that usually happen with frequency under seipin gain-of-function. (a) Seipin gain-of-function through overexpression in adipogenic models. Adipocyte maturation was not impaired, but other parameters are still not clear. (b) Seipin gain-of-function through mutations in adipogenic models. Adipocyte maturation was not impaired even with ER stress. (c) Seipin gain-of-function through overexpression in nonadipogenic models. There was TG synthesis decrease, with lipolysis increase. (d) Seipin gain-of-function through mutations in nonadipogenic models. TG synthesis impairment was observed together with lipolysis increase and strong and significant ER stress. (b) and (d) models are related to seipinopathy. Positive symbols represent a process that is usually increased, while the negative symbols represent the opposite. The interrogation symbol represents a process that needs to be studied further. Pieces of the illustrations are from the SMART website [40].