Exploring Seipin: From Biochemistry to Bioinformatics Predictions

Figure 2

Alignment of transmembrane regions of seipin. Multiple alignments of seipin isoforms were performed through T-Coffee [32]. Many authors predicted the transmembrane regions of seipin and the amino acid positions are reviewed in Table 1 [4, 6, 14, 33, 34]. It is possible to observe that, even with differences, some regions are conserved in the prediction for the same isoform or between different isoforms. Isoform 2 was omitted due to the low number of works with it. Pink color represents identical alignments; yellow corresponds to similar alignments; and green regions show different alignments. corresponds to an equal match. Cons: consensus sequence.

(a) First seipin transmembrane region

(b) Second seipin transmembrane region