Exploring Seipin: From Biochemistry to Bioinformatics Predictions

Figure 11

Theoretical model for seipin. (a) Seipin seems to have a core/looping region with more importance for nonadipogenic cells. This region can interact with GPAT3 and downregulate its activity, compromising TG synthesis. (b) Seipin loss-of-function in nonadipogenic cells seems to have the opposite behavior of the situation proposed in “(a)”. (c) Seipin also seems to have a C terminus region with more importance for adipogenesis. This region can interact with lipin1 and 14-3-3β to promote TG synthesis and adipogenesis. (d) Seipin loss-of-function in adipogenic cells seems to have the opposite behavior of the situation proposed in “(c)”. AGPAT: 1-acyl-sn-glycerol-3-phosphate acyltransferase; DG: diacylglycerol; DGAT: diacylglycerol o-acyltransferases; G3P: glycerol-3-phosphate; GPAT: glycerol-3-phosphate acyltransferase; LPA: lysophosphatidic acid; PA: phosphatidic acid; PPARγ: peroxisome proliferator-activated receptor gamma; TG: triacylglycerol.

(a) Normal situations in nonadipogenic cells

(b) Seipin loss-of-function in nonadipogenic cells

(c) Normal situations in adipogenic cells

(d) Seipin loss-of-function in adipogenic cells