HARE-Mediated Endocytosis of Hyaluronan and Heparin Is Targeted by Different Subsets of Three Endocytic Motifs

Figure 7

Different sets of HARE CD endocytic motifs are functional during HA versus Hep endocytosis. The four HARE endocytic motifs (boldface) examined are denoted by M1 (YSYFRI²⁴⁸⁵), M2 (FQHF²⁴⁹⁵), M3 (NPLY²⁵¹⁹), and M4 (DPF²⁵³⁴). The two different subsets of three of these motifs active in the coated pit mediated endocytosis of HA (M1, M2, and M3) or Hep (M1, M3, and M4) are highlighted by brackets. M3 is highlighted in red to indicate its special significance as the only motif of the three we were able to test (M2, M3, and M4) that enabled HARE to target coated pit mediated endocytosis of both HA and Hep.