Methyl Jasmonate: Putative Mechanisms of Action on Cancer Cells Cycle, Metabolism, and Apoptosis

Figure 3

5-Lipoxygenase (5-LOX) pathway in mammalian cells. Methyl jasmonate (MJ) can inhibit this pathway at the 5-LOX level in cancer cells [47]. The multiple consequences of this effect are (1) blocking 5-lipoxygenase-mediated ROS production (lipid hydroperoxides—LOOH); (2) antiproliferative effect linked to inhibition of 5-HETE production; (3) inhibition of leukotrienes production.