Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced 𝛼-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species

Figure 3

Comparison of simulated and experimentally determined concentrations of TCAC intermediates. Green bars indicate the concentration range of reported experimental values [21–29]. Blue bars (normal state) and red bars (50% inhibition of KGDHC) indicate variations of concentration when varying the energetic load between 33% and 100% of maximum.