Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced -Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species
Figure 10
ROS production at inhibition of KGDHC. Levels of fully reduced flavin ((a) and (b)), semi-ubiquinone at n-site bound to complex I ((c) and (d)) and semi-ubiquinone at p-site bound to complex III ((e) and (f)) at various inhibitions (a) of KGDHC. The levels are depicted versus the mitochondrial membrane potential ((a), (c), and (e)) and the ATP production rate ((b), (d) and (f)). Values except membrane potential are normalized to the reference state.
