Band 3 Missense Mutations and Stomatocytosis: Insight into the Molecular Mechanism Responsible for Monovalent Cation Leak

Figure 1

Topology of the membrane spanning domain of human AE1 with 13 α helices, according to Zhu et al. [29]. Aminoacids that are substituted in response to the different point mutations in AE1 gene are labelled by circles. Each of these mutations is associated with hereditary haemolytic anaemia characterized by cation leaky red cells.