The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration

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</svg> microarray analysis of mRNA abundance in PSP versus normal control brains. Six chips were generated and statistically analyzed. Signals <svg height="11.6" id="M42" style="vertical-align:-0.546pt" version="1.1" viewbox="0 0 35.025002 11.6" width="35.025002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> (red) refer to underexpressed genes, while signals <svg height="11.6" id="M43" style="vertical-align:-0.546pt" version="1.1" viewbox="0 0 22.987499 11.6" width="22.987499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> (green) show overexpressed genes. The figure shows some genes out of 64 genes which are differentially regulated in PSP.: TUBA: <svg height="7.9499998" id="M44" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 9.7749996 7.9499998" width="9.7749996" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>-tubulin; DUSP1: dual specifity protein phosphatase 1; PPP2R1A: serine/threonine protein phosphatase 2A; MAL: myelin and lymphocyte protein.</table>

International Journal of Cell Biology

fig2

Figure 2

Figure 2: The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration 

Figure 2 | The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration 