Lowering Caveolin-1 Expression in Human Vascular Endothelial Cells Inhibits Signal Transduction in Response to Shear Stress

<table>Activation of mechanotransduction pathways by
shear. HUVECs were subjected to shear stress for different periods.
Subsequently, the amount of phosphorylated Akt and ERK1/2 was determined by
immunoblotting. After 10 minutes, phosphorylation levels were significantly
higher (<svg height="11.9" id="M28" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 54.674999 11.9" width="54.674999" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">1</tspan>
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</svg>, Student’s <svg height="9.125" id="M29" style="vertical-align:-0.11285pt" version="1.1" viewbox="0 0 5.0124998 9.125" width="5.0124998" xmlns="http://www.w3.org/2000/svg">
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</svg>-test) compared to levels in statically cultured cells. After 30 minutes, this significant increase was no
longer detected.</table>

International Journal of Cell Biology

fig1

Figure 1

Figure 1: Lowering Caveolin-1 Expression in Human Vascular Endothelial Cells Inhibits Signal Transduction in Response to Shear Stress 