Silica/Protein and Silica/Polysaccharide Interactions and Their Contributions to the Functional Properties of Derived Hybrid Wound Dressing Hydrogels

Figure 4

Chemical modification of silica and their contributions to their covalent bonding to proteins through (a) aminosilica-protein imine bonds mediated by bifunctional aldehyde crosslinkers (glyoxal; GA: glutaraldehyde; SQA: squarid acid); (b) radical activated reactions between vinyl-silica and maleic anhydride protein; (c) polysaccharide coupling via the epoxy opening in silica modified with epichlorohydrin at 70°C in dimethylformamide (DMF).

(a)

(b)

(c)